Multi-pass flow cytometry
TheMarchissue illustrates that barcoding cells with microparticles that emit near-infrared laser light allows for multi-pass flow cytometry with more markers and fewer colours.
Featured
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Techniques for supercharging academic writing with generative AI
Generalist large language models can elevate the quality and efficiency of academic writing.
- Zhicheng Lin
Comment
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Towards on-skin analysis of sweat for managing disorders of substance abuse
A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders.
- Noe Brasier
- Juliane R. Sempionatto
- Wei Gao
Comment
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A framework for integrating artificial intelligence for clinical care with continuous therapeutic monitoring
A framework for integrating continuous therapeutic monitoring and the development of AI for clinical care may improve patient and health-system outcomes by tightening feedback loops between patient health, clinical interactions and the development of AI models.
- Emma Chen
- Shvetank Prakash
- Pranav Rajpurkar
Perspective
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Towards multifunctional robotic pills
This Perspective discusses progress in the development of robotic capsules for oral drug delivery and the challenges of realizing sophisticated multifunctional robotic pills that can function as closed-loop systems.
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- Nelly Askarinam
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Perspective
Current issue
Methods, techniques, assays and protocols
Editorial
Deep screening of antibody–antigen affinities
- Timothy A. Whitehead
News & Views
Screening for drivers of SARS-CoV-2 uptake
- Alexis Autour
- Christoph A. Merten
News & Views
Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
- Benjamin T. Porebski
- Matthew Balmforth
- Philipp Holliger
ArticleOpen Access
Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
- Matthew E. H. White
- Ludwig R. Sinn
- Markus Ralser
ArticleOpen Access
Identification, sorting and profiling of functional killer cells via the capture of fluorescent target-cell lysate
- Yen Hoon Luah
- Tongjin Wu
- Lih Feng Cheow
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells
The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines
The densities of blood vessels and of tumour-associated macrophages are key predictive features of the degree of accumulation of polymeric and liposomal nanomedicines, as shown for specimens of mouse and human tumours.
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A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice
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Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression
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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes
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Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity
The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates avenues for enhancing the efficacy of T cell-targeted immune therapies.
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Mineralized bacteria as an immunotherapy agent against various cancer types
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Affinity maturation of CRISPR-engineered B cell receptors in vivo
CRISPR–Cas12a was used to directly replace mouse antibody variable chain genes with human versions in primary B cells. The edited cells underwent affinity maturation in vivo, improving the potency of HIV-1 and SARS-CoV-2 neutralizing antibodies without loss of bioavailability. Affinity maturation of edited cells also enables new vaccine models and adaptive B cell therapies.
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Thermally sentient bionic limbs
Naturally perceived thermal sensations can be evoked as though originating from a prosthetic limb by taking advantage of sensory reinnervation of the residual limb after amputation.
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Screening for drivers of SARS-CoV-2 uptake
Genetic and cellular drivers of the cellular uptake of SARS-CoV-2 can be screened at high throughput via droplet microfluidics and size-exclusion methods for the analysis of the formation of fusions between cells expressing the virus’s spike protein and cells expressing the protein’s receptor.
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Designing stable humanized antibodies
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Subcutaneous pancreatic islet transplantation without immunosuppression
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The myriad ways to engineer cells
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Methods, techniques, assays and protocols
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Towards on-skin analysis of sweat for managing disorders of substance abuse
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